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Literature summary extracted from

  • Ghersi, G.; Zhao, Q.; Salamone, M.; Yeh, Y.; Zucker, S.; Chen, W.T.
    The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices (2006), Cancer Res., 66, 4652-4661.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.21.B28 medicine protease complex consisting of seprase and dipeptidylpeptidase IV in endothelial cells that are activated to migrate and invade in the extracellular matrix in vitro and are coexpressed with the three major protease systems matrix metalloproteinase, plasminogen activator, and type II transmembrane serine protease, at the cell surface and organize as a complex at invadopodia-like protrusions Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.B28 97000
-
 2 * 97000 Homo sapiens
3.4.21.B28 160000 170000
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B28 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B28 breast cancer cell
-
 Homo sapiens
-
3.4.21.B28 endothelial cell colocalized with dipeptidylpeptidase IV in endothelial cells of capillaries, but not of large blood vessels, in invasive breast ductal carcinoma in vivo Homo sapiens
-
3.4.21.B28 HUVEC cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B28 Gelatin + H2O
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.B28 homodimer 2 * 97000 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B28 seprase
-
 Homo sapiens